Moreover, little is known about the potential influence of MPV and its change on mortality in a homogenous group of patients with sepsis. Only a few studies have revealed the relationship between MPV and prognosis in infectious diseases, including sepsis. Although the underlying mechanism is not yet completely understood, the sophisticated interaction of platelets with pathogens and endothelial cells may culminate in sepsis, a severe pathophysiologic cascade characterized by significant reductions in platelet counts and platelet dysfunction. The time course of platelet counts and its function in critically ill patients, especially in patients with sepsis, have been elucidated by several previous studies. Additionally, MPV has been considered an index for inflammation, disease activity, and efficacy of anti-inflammatory treatment in several chronic inflammatory disorders, such as inflammatory bowel disease, rheumatoid arthritis, and ankylosing spondyloarthritis. Over the past decade, several studies have shown that increased MPV is an independent risk factor for cardio- and cerebrovascular diseases and is associated with poor clinical outcomes of these diseases. Increased platelet volume and size reflects the existence of a thrombotic and inflammatory milieu thus, MPV is suggested as a possible marker of platelet function and activation. The mean platelet volume (MPV) describes the average size of platelets in a blood sample and is routinely measured by automated hematology analyzers using either electrical impedance or optical fluorescence method. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are within the paper.įunding: This work was supported by the Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, and a grant of the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI10C2020). Received: SeptemAccepted: JanuPublished: March 5, 2015Ĭopyright: © 2015 Kim et al. ![]() PLoS ONE 10(3):Īcademic Editor: Chiara Lazzeri, Azienda Ospedaliero-Universitaria Careggi, ITALY (2015) An Increase in Mean Platelet Volume from Baseline Is Associated with Mortality in Patients with Severe Sepsis or Septic Shock. Citation: Kim CH, Kim SJ, Lee MJ, Kwon YE, Kim YL, Park KS, et al.
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